Study # 407

What is the purpose of the study?
To determine whether clonidine, given to abstinent patients maintained on buprenorphine, prevents relapse to opiate use more effectively than placebo.

Who can participate in the study?
This study is accepting men and women who:

• Are at least 18 years of age
• Are physically dependent on heroin, methadone, or pain pills
• Are seeking treatment for opiate addiction
• Are able to come to the clinic 7 days a week

What will participants be asked to do?
The study lasts up to 36 weeks (9 months).

For research purposes, participants will:

• Use electronic diaries that are provided as part of the study
• Provide urine samples 3 times a week
• Be asked to take capsules that may contain clonidine (a drug used to treat high blood pressure) or placebo (a pill with no drug)
• Once participants have been on buprenorphine for 6 weeks, they will be required to abstain from illicit opiates for at least 2 weeks to stay in the study

Participants will also receive research-related treatment and support:

• Have a brain scan MRI
• Have a sample of spinal fluid taken

Participants will receive:

• Receive daily buprenorphine as a tablet dissolved under
  the tongue
• Individual counseling once a week
• Help with transportation
• Help connecting with community services

Where is the study taking place?
The NIDA Intramural Research Program is located on the Johns Hopkins Bayview campus in east Baltimore.

How much does it cost?
There is no cost for participation.

Will I receive payment of some kind?
Participants are paid for some research activities.

How can I find out if I’m eligible to participate?
Call 1-866-START NOW (1-866-782-7866) for a confidential screening.

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