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Alcohol Studies at NIDA

If you drink alcohol, you might be able to join one of our research studies. It’s free to join, and you will be paid for your time and local travel. All study participants receive ongoing medical care while they are in the study to monitor their health and safety.

Effects of an experimental drug on alcohol craving

Study ID: 19-DA-N075

The purpose of this study is to test whether an experimental drug affects the craving to consume alcohol. This study is accepting men and women who are 18–70 years of age, are in generally good health, drink alcohol, and are willing to stop drinking alcohol during the study. Participation includes inpatient stays, for approximately 21 days, at the National Institute on Drug Abuse’s overnight center in East Baltimore.

For research purposes, participants will:

  • Take the study drug or placebo by mouth twice a day for half of the study and then switch and take the other one for the second half
  • Taste several sweet solutions
  • Have physical exams performed and vital signs taken
  • Be exposed to alcohol, water, and food cues in a room that looks like a bar
  • Answer questions on a computer
  • Participate in virtual reality tasks

This study takes place at the NIDA Intramural Research Program located on the Johns Hopkins Bayview campus in east Baltimore. There is no cost for participation, and participants are paid for their time and travel

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Effects of a new behavioral intervention on alcohol craving and drinking

Study ID: 16-DA-N140

The purpose of this study is to see if we can use visual imagery and behavioral techniques to reduce alcohol craving and drinking in people who drink. This study is accepting men and women who are 21-65 years of age, are in generally good health, have consumed alcoholic beverages every week in the last 3 months and like the sight and smell of alcohol. Participation includes 6 study visits over 4 weeks lasting up to 4 hours each with the exception of the last study visit which lasts approximately 7.5 hours.

For research purposes, participants will:

  • Complete questionnaires about your mood and behavior, including alcohol craving and drinking
  • Answer questions on a custom-designed app using a study-issued smartphone
  • Receive a physical exam
  • Provide blood, urine samples

This study takes place at the NIDA Intramural Research Program located on the Johns Hopkins Bayview campus in east Baltimore. There is no cost for participation and participants are paid for their time and travel.

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Ketogenic Diet in Alcoholism

Study ID: 17-AA-0152

This research study is investigating if eating a ketogenic diet (including high fat, low carbohydrate shakes) will have an effect on symptoms of alcohol withdrawal and on brain function in patients with alcohol use disorder undergoing inpatient treatment of alcohol detoxification.

Research participation includes participating in our inpatient alcohol treatment program at the NIH Clinical Center in Bethesda, Maryland. While in our program participants will be assigned to a meal plan for 3 or more weeks. The meal plan will consist of a ketogenic diet (high fat, low carbohydrates) or standard American diet. Activity level and sleep patterns will be monitored. Participants will also have a physical exam, medical history including alcohol and drug use, MRI scan, blood work, and urine analysis.

The study is enrolling 18-75 year olds who are willing and able to provide written informed consent. You may be eligible if you have a moderate to severe alcohol disorder and are seeking treatment for your alcohol use.

You do not need to pay to participate in this study. You will receive inpatient alcohol detoxification and treatment at no cost. You will be financially compensated for your participation. NIH will provide travel to and from the NIH Clinical Center within the United States.

For more details, call NIH Clinical Center Office of Patient Recruitment at 1-800-411-1222 1-800-411-1222

In addition to considering NIDA research studies, anyone interested in alcohol studies might want to consider research studies at the National Institute on Alcohol Abuse and Alcoholism (NIAAA) in Bethesda, Maryland. NIAAA is the lead agency for U.S. research on alcohol use disorder (AUD) and other health and developmental effects of alcohol use. NIAAA’s mission is to generate new knowledge about the effects of alcohol on health and well-being and share that information with health care providers, researchers, policy makers, and the public.

Is a NIDA Alcohol Research Study an Option for Me?

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