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The goal of all NIDA studies is to find out how substance use affects the brain and body.

Nicotine Studies at NIDA

If you currently smoke cigarettes, you might be able to join one of our research studies. We have studies for people interested in quitting and for people who do not currently wish to quit. It’s free to join, and you will be paid for your time and local travel. All study participants receive ongoing medical care while they are in the study to monitor their health and safety.

Current Nicotine Studies

The purpose of this study is to develop new ways to measure nicotine dependence severity that may be useful in predicting success in smoking cessation and in development of new smoking cessation treatment targets. This study is accepting men and women who are 18 to 60 years of age, in generally good health, currently smoking cigarettes and interested in quitting smoking.

What will participants be asked to do?

  • Attend 16 visits over 1 year
  • 1 session for consent, orientation and training, lasting about 3–4 hours
  • 6 MRI scans, total visit length is about 5 ½–6 ½ hours each
  • 12 weekly counseling (treatment) sessions, lasting about 1 hour each
  • Use e-cigarettes as nicotine replacement
  • Stop using all nicotine products for 2 days early in the study
  • Make a quit attempt and stop using all nicotine products for at least 1 year
  • 4 blood draws to obtain genetic and nicotine information
  • Brief medical assessment at each visit
  • Answer questionnaires about how you think and feel at each visit
  • Complete various thinking tasks inside and outside of the MRI

This study takes place at the NIDA Intramural Research Program located on the Johns Hopkins Bayview campus in east Baltimore. There is no cost for participation and participants are paid for their time and travel.

Call 1-800-535-8254 for a confidential screening.

The purpose of this study is to develop new ways to measure nicotine dependence severity that may be useful in guiding development of new smoking cessation treatment targets. This study is accepting men and women who are 18 to 60 years of age and in generally good health.

This study is looking for participants who are

  • Current smokers not interested in quitting at this time
  • Past smokers who have successfully quit for at least 1 year
  • Non-smokers

For research purposes, participants will be asked to:

  • Attend 1-2 visits
  • 1 session for consent, orientation and training, lasting about 3 hours
  • 1 MRI scan, total visit length is about 4 to 5 hours
  • 1 blood draw to obtain genetic information
  • Complete a brief medical assessment at each visit
  • Answer questionnaires about how you think at feel at each visit
  • Complete various thinking tasks inside and outside of the MRI

This study takes place at the NIDA Intramural Research Program located on the Johns Hopkins Bayview campus in east Baltimore. There is no cost for participation and participants are paid for their time and travel.

Call 1-800-535-8254 for a confidential screening.

The purpose of this study is to examine the effects of a brain stimulation device called Transcranial Direct Current Stimulation, also known as tDCS in both smokers and non-smokers. tDCS has the potential to be used as a treatment for smoking addiction in the future.

This study is accepting men and women who are 18 to 60 years of age, are current daily smokers and are in generally good health. Participation includes 3 study visits lasting 4-8 hours each.

For research purposes, participants will:

  • Complete multiple tDCS sessions lasting about 25 minutes each
  • Complete MRI scan(s)
  • Answer questionnaires
  • Receive a physical exam
  • Provide blood, urine samples

This study takes place at the NIDA Intramural Research Program located on the Johns Hopkins Bayview campus in east Baltimore. There is no cost for participation and participants are paid for their time and travel.

Call 1-800-535-8254 for a confidential screening.


Smoking Cessation Study

Is a NIDA Nicotine Research Study an Option for Me?

Answer a few questions to see if you qualify for an in-person screening appointment.

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